Research On Mitosis Structure to understand the inside of cancer cells

In Biophysical Society, mitosis is a part of cell biology which results in two parts of daughter cells each having the same number and kind of chromosomes as the parent nucleus, typical of ordinary tissue growth. This involves the great majority of the cell divisions that happen in your body. Mitosis, a process of cell duplication, or reproduction.

Cell division is a very complicated sequence of proteins and molecules that divide the cell. While scientists are familiar with MTOCs’ existence and the role they play in cell division, their actual physical structure remains poorly understood. Researchers are now trying to decipher their molecular architecture. The team of researchers is trying to decipher the molecular architecture of the MTOC.

Mitosis Structure creates within the cell which provides the stability within the network of microtubules that act like scaffolding within the cell. Near about 1,000 proteins are associated with the MTOC in animal cells, but few of these proteins have been assigned a particular function.

Within these simpler organisms, the spindle pole body (SPB) functions like the MTOC. Unlike in animal cells, the SPB of yeast contains only 18 proteins and Viswanath has initially focused on five core proteins: Spc110, Spc42, Cnm67, Spc29, and Cmd1.

It is found that the Spc110 protein provides a greater function in the SPB than originally believed by using multiple techniques such as structural modeling, X-ray scattering, X-ray crystallography and electron microscopy. At first, scientists thought these proteins acted as mere spacers holding pieces of the SPB architecture in place, but now it is believed these proteins may provide a binding surface for this architecture. This information can help understand the function of the human cell equivalent of SPBs called centrosomes. Cancer cells in most forms of cancer reveal abnormalities in the size or structure of centrosomes. Future experiments are necessary to identify the position of other key proteins, like Spc29, a critical protein in the SPB core and to eventually identify its specific function.

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